If you are suffering from Tuberculosis.
Recently taken any vaccine or if you have to take any vaccine in the near future.
Are taking TNF-α blockers. You have a higher risk of infection if you are taking the two at the same time.
If you are suffering from COPD (Chronic obstructive pulmonary disease). Patients with COPD may have worsening of cough/ breathlessness with orencia.
Have or have had viral hepatitis.
Patients taking Orencia are at higher risk of developing infections since it depresses the immune system.
There have been rare cases of cancer (lung cancer & lymphoma) in patients taking Orencia. However, the exact role of Orencia in causation of cancer is not established.
1)Moreland LW, Alten R, Van den Bosch F,
Appelboom T, Leon M, Emery P, Cohen S, Luggen M, Shergy W,
Nuamah I, Becker JC: Costimulatory blockade in patients with
rheumatoid arthritis: a pilot, dose-finding, double-blind,
placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y
eighty-five days after the first infusion. Arthritis Rheum
2)Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, Russell A, Dougados M, Emery P, Nuamah IF, Williams GR, Becker JC, Hagerty DT, Moreland LW: Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003, 349:1907- 1915.
3) Kremer JM, Genant HK, Moreland LW, Russell AS, Emery P, Abud-Mendoza C, Szechinski J, Li T, Teng J, Becker JC, Westhovens R: Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate. Arthritis Rheum 2008, 58:953-963.
Rituximab (Mabthera/ Reditux/ Rituxan) for Rheumatoid arthritis
Tociliziumba (Actemra) for rheumatoid artritis