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How to overcome nausea related to Methotrexate

1) Spread out the Methotrexate dose- The total dose of Methotrexate can be divided & taken over 2 days every week. For eg. You may take 1 tablet of methotrexate (5mg) after lunch & dinner on Saturday & Sunday instead of the entire dose once on Sunday.

2) You may take the dose at bedtime if the dose after lunch is causing nausea.

3) Take the dose after food instead of taking it before food.

4) You may take an antiemetic medicine along with Methotrexate.

5) Take folic acid on the all days except the day of methotrexate.

6) If nothing works, you can shift over to injection Methotrexate. A Family Physician can administer it to you (intramuscular) or you can take it yourself subcutaneously (just like insulin shots).


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Created on: April 2007
Last updated on: Feb 2015
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