Methotrexate—This drug may remain in the liver upto 100–120 days. Hence, it should be stopped at least 3–4 months prior to cocnception to avoid potential risk to the unborn baby. You should be taking folic acid during this period and should continue taking it thereafter.

Leflunomide—This drug remains in the system for as long as 3 years. If you are on Leflunomide and plan to conceive, you need a wash out therapy. The same includes a drug called cholestyramine to be taken for 11 days to wash out leflunomide from the body. You should plan pregnancy 3 months after the wash out therapy.

Sulphasalazine—is considered safe in pregnancy and need not be stopped.

Hydroxychloroquine—is considered safe in pregnancy.

Do consult your Rheumatologist before you plan to conceive for the necessary changes in your anti—arthritis drugs.

Created on: April 2007

Last updated on: April 2011